THREE QUESTIONS : FIRST QUESTION: In your opinion , what is the proportion of " chemicals " ( future drugs ) that have shown efficacy in animal model (mouse, ... ) FINALLY become drugs used in humans ? Have you any idea? ? For all the discovered and studied products that show A REAL POSITIVE ACTIVITY IN AN ANIMAL MODEL (such as PBI- 4050 Prometic ) ... most products do not go to market. Two main reasons: (1) products that help mice ... do NOT WORK FOR humans ... AND / OR ... (2) SECONDARY OR frankly disturbing humans TOXIC EFFECTS prevent their use . THE ANSWER? ? LESS THAN 10 % of the products that have demonstrated an interesting clinical effect in animals RESULT OF MERCHANTABILITY AND USE IN HUMANS . Less than 10% ... _____________________________________________________________________ SECOND QUESTION: What is the average estimated cost of drug development from early phase I clinical trials in humans? ? The average cost is about U.S. $ 100 MILLION $ ... ____________________________________________________________________ THIRD QUESTION : What is the average duration of clinical trials in humans before marketing a new drug ? FIVE TO TEN YEARS ... There are exceptions and "fast -tracks " in certain situations . In the case of PBI- 4050 (which appears VERY INTERESTING AND A POSSIBLE BLOCKBUSTER), I think there are 3 conclusions at this stage : 1. The chances of success ... and so market and clinical use in humans ... are about 10 % 2 . From now , clinical studies in humans could cost $ U.S. $ 100 million (and an association with a big pharma player is highly probable ) 3 . Time before marketing should be at least 3-5 years ... in the event of a "fast -track " ! ... ____________________________________________________________________ PS: I am IN and fairly heavily invested in this title ... I just try not to wear rosy glasses ...